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TABLE OF CONTENTS2
ES350_OM_OM33B64U_(U)
For your information ................................... 8
Reading this manual................................... 12
How to search ..............................................13
Pictorial index ............................................... 14
1-1. For safe useBefore driving................................. 26
For safe driving .............................. 28
Seat belts .......................................... 30
SRS airbags ..................................... 35
Front passenger occupant classification system.................. 44
Safety information for children ................................... 50
Child restraint systems .................51
Installing child restraints............. 55
Exhaust gas precautions ............ 64
1-2. Theft deterrent system Engine immobilizer system....... 65
Alarm ..................................................67
2. Instrument cluster Warning lights and indicators .............................. 70
Gauges and meters ...................... 74
Multi-information display .......... 78
Fuel consumption information ................................... 84 3-1. Key information
Keys .................................................... 90
3-2. Opening, closing and locking the doors and trunk
Doors ................................................. 93
Trunk................................................... 99
Smart access system with push-button start ............ 106
3-3. Adjusting the seats Front seats........................................ 114
Driving position memory........... 115
Head restraints .............................. 119
3-4. Adjusting the steering wheel and mirrors
Steering wheel .............................. 122
Inside rear view mirror .............. 124
Outside rear view mirrors........ 126
3-5. Opening, closing the windows and moon roof
Power windows............................. 129
Moon roof .......................................132
1For safety and security
2Instrument cluster
3Operation of each
component

ES350_OM_OM33B64U_(U)
11
The SRS airbag and seat belt pretensioner devices in your Lexus contain explosive
chemicals. If the vehicle is scrapped with the airbags and seat belt pretensioners not
deployed, this may cause an acci dent such as fire. Be sure to have the systems of the SRS
airbag and seat belt pretensioner removed an d disposed of by a qualified service shop or
by your Lexus dealer before you scrap your vehicle.
Special handling may apply, See www.dts c.ca.gov/hazardouswaste/perchlorate.
Your vehicle has components that may contain perchlorate. These components may
include airbag, seat belt pretensioners, and wireless remote control batteries.
Scrapping of your Lexus
Perchlorate Material
WA R N I N G
■General precautions while driving
●Obey all traffic laws
●The driver is responsible for the proper operation of the vehicle, including evaluation
of weather conditions and road conditions.
Driving under the influence: Never drive your vehicle when under the influence of
alcohol or drugs that have im paired your ability to operate your vehicle. Alcohol and
certain drugs delay reaction time, impair judgment and reduce coordination, which
could lead to an accident that could result in death or serious injury.
Defensive driving: Always drive defensively. Anticipate mistakes that other drivers or
pedestrians might make and be ready to avoid accidents.
Driver distraction: Always give your full atte ntion to driving. Anything that distracts the
driver, such as adjusting controls, talking on a cellular phone or reading can result in a
collision causing death or serious injury to you, your occupants or others.
■General precaution regarding children’s safety
Never leave children unattended in the vehicle, and never allow children to have or use
the key.
Children may be able to start the vehicle or sh ift the vehicle into neutral. There is also a
danger that children may injure themselves by playing with the windows, the moon
roof, or other features of the vehicle. In addition, heat build-up or extremely cold tem-
peratures inside the vehicl e can be fatal to children.

23Pictorial index
ES350_OM_OM33B64U_(U)
Inside rear view mirror . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 124
Sun visors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 384
Vanity mirrors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 384
Interior lights
*1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 376
Pe r s o n a l l i g h t s
*1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 376
Moon roof switches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 132
“SOS” button
*2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 402
Garage door opener switches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .P. 391
*1: The illustration shows the front, but they are also equipped in the rear.
*2: If equipped
1
2
3
4
5
6
7
8

391-1. For safe use
ES350_OM_OM33B64U_(U)
1
For safety and security
WA R N I N G
■SRS airbag precautions
●Do not hang coat hangers or hard objects on the coat hooks. All of these items could
become projectiles and may cause death or serious injury, should the SRS curtain
shield airbags deploy.
●If a vinyl cover is put on the area where the SRS knee airbag will deploy, be sure to
remove it.
●Do not use seat accessories which cover th e parts where the SRS side airbags inflate
as they may interfere with inflation of th e airbags. Such accessories may prevent the
side airbags from activating correctly, disa ble the system or cause the side airbags to
inflate accidentally, resulting in death or serious injury.
●Do not lean against the door, the roof side rail
or the front, side and rear pillars.
●Do not allow anyone to kneel on the passen-
ger seats toward the door or put their head or
hands outside the vehicle.
●Do not attach anything to or lean anything
against areas such as the dashboard, steering
wheel pad, lower portion of the instrument
panel and door of the glove box.
These items can become projectiles when the
SRS driver, front passenger and knee airbags
deploy.
●Do not attach anything to areas such as a
door, windshield glass, side door glass, front
or rear pillar, roof side rail and assist grip.

401-1. For safe use
ES350_OM_OM33B64U_(U)
■If the SRS airbags deploy (inflate)
●Slight abrasions, burns, bruising etc., may be sustained from SRS airbags, due to the
extremely high speed deployment (inflation) by hot gases.
●A loud noise and white powder will be emitted.
●Parts of the airbag module (steering wheel hub, airbag cover and inflator) as well as the
seats, parts of the front and rear pillars, and roof side rails may be hot for several min-
utes. The airbag itself may also be hot.
●The windshield may crack.
●For Lexus Enform Safety Connect subscribers, if the SRS airbags deploy or in the event
of a severe rear-end collision, the system is designed to send an emergency call to the
response center, notifying them of the vehicl e’s location (without needing to push the
“SOS” button) and an agent will attempt to speak with the occupants to ascertain the
level of emergency and assistance required . If the occupants are unable to communi-
cate, the agent automatically treats the call as an emergency and helps to dispatch the
necessary emergency services. ( P. 4 0 2 )
WA R N I N G
■SRS airbag precautions
●Do not strike or apply signif icant levels of force to the area of the SRS airbag compo-
nents.
Doing so can cause the SRS airbags to malfunction.
●Do not touch any of the component parts immediately after the SRS airbags have
deployed (inflated) as they may be hot.
●If breathing becomes difficult after the SRS airbags have deployed, open a door or
window to allow fresh air in, or leave the vehicl e if it is safe to do so. Wash off any resi-
due as soon as possible to prevent skin irritation.
●If the areas where the SRS airbags are stored, such as the steering wheel pad and
front and rear pillar garnishes are damaged or cracked, have them replaced by your
Lexus dealer.
■Modification and disposal of SRS airbag system components
Do not dispose of your vehicle or perform any of the following modifications without
consulting your Lexus dealer. The SRS airb ags may malfunction or deploy (inflate)
accidentally, causing de ath or serious injury.
●Installation, removal, disassembl y and repair of the SRS airbags
●Repairs, modifications, removal or replac ement of the steering wheel, instrument
panel, dashboard, glove box, seats or seat upholstery, front, side and rear pillars or
roof side rails
●Repairs or modifications of the front fend er, front bumper, or side of the occupant
compartment
●Installation of a grille guar d (bull bars, kangaroo bar, etc.), snow plows, winches or
roof luggage carrier
●Modifications to the vehicle’s suspension system
●Installation of electronic devices such as mobile two-way radios and CD players
●Modifications to your vehicle for a person with a physical disability

431-1. For safe use
ES350_OM_OM33B64U_(U)
1
For safety and security
■When to contact your Lexus dealer
In the following cases, the vehicle will re quire inspection and/or repair. Contact your
Lexus dealer as soon as possible.
●Any of the SRS airbags have been inflated.
●The front of the vehicle is damaged or
deformed, or was involv ed in an accident that
was not severe enough to cause the SRS front
airbags to inflate.
●A portion of a door or its surrounding area is
damaged or deformed, or the vehicle was
involved in an accident that was not severe
enough to cause the SRS side and curtain
shield airbags to inflate.
●The pad section of the steering wheel, dash-
board near the front passenger airbag or
lower portion of the instrument panel is
scratched, cracked, or otherwise damaged.
●The surface of the seats with the side airbag is
scratched, cracked, or otherwise damaged.
●The portion of the front pillars, rear pillars or
roof side rail garnishes (padding) containing
the curtain shield airbag s inside is scratched,
cracked, or otherwise damaged.

501-1. For safe use
ES350_OM_OM33B64U_(U)
Safety information for children
●It is recommended that children sit in the rear seats to avoid accidental con-
tact with the shift lever, wiper switch etc.
●Use the rear door child-protector lock or the window lock switch to avoid
children opening the door while driving or operating the power window acci-
dentally. ( P. 9 6 , 1 2 9 )
●Do not let small children operate equi pment which may catch or pinch body
parts, such as the power window, hood, trunk, seats etc.
Observe the following precautions when children are in the vehicle.
Use a child restraint system appropriate for the child, until the child becomes
large enough to properly wear the vehicle’s seat belt.
WA R N I N G
Never leave children unattended in the vehicle, and never allow children to have or use
the key.
Children may be able to start the vehicle or sh ift the vehicle into neutral. There is also a
danger that children may injure themselves by playing with the windows, the moon roof
or other features of the vehicle. In additi on, heat build-up or extremely cold tempera-
tures inside the vehicle can be fatal to children.

531-1. For safe use
ES350_OM_OM33B64U_(U)
1
For safety and security
WA R N I N G
■Child restraint precautions
●For effective protection in automobile a ccidents and sudden stops, a child must be
properly restrained, using a se at belt or child restraint system depending on the age
and size of the child. Holding a child in your arms is not a substitute for a child restraint
system. In an accident, the child can be crushed against the windshield, or between
you and the vehicle’s interior.
●Lexus strongly urges the use of a proper child restraint system that conforms to the
size of the child, installed on the rear seat . According to accident statistics, the child is
safer when properly restrained in th e rear seat than in the front seat.
●Never install a rear-facing child restraint system on the front passenger seat even if
the “AIR BAG OFF” indicator light is illuminated.
In the event of an accident, the force of the rapid inflation of the front passenger air-
bag can cause death or serious injury to the child if the rear-facing child restraint sys-
tem is installed on the front passenger seat.
●A forward-facing child restraint system ma y be installed on the front passenger seat
only when it is unavoidable. A child restra int system that requires a top tether strap
should not be used in the front passenger seat since there is no top tether strap
anchor for the front passenger seat. Adjust the seatback as upright as possible and
always move the seat as far back as possible even if the “AIR BAG OFF” indicator
light is illuminated, because the front passenger airbag could inflate with considerable
speed and force. Otherwise, the child may be killed or seriously injured.
●Do not use the seat belt extender when inst alling a child restraint system on the front
or rear passenger seat. If installing a child restraint system with the seat belt extender
connected to the seat belt, the seat belt w ill not securely hold the child restraint sys-
tem, which could cause death or serious injury to the child or other passengers in the
event of a sudden stop, sudden swerve or accident.
●Do not allow the child to lean his/her head or any part of his/her body against the
door or the area of the seat, front and rear pillars or roof side rails from which the SRS
side airbags or SRS curtain shield airbags depl oy even if the child is seated in the child
restraint system. It is dangerous if the SR S side airbags and curtain shield airbags
inflate, and the impact could cause de ath or serious injury to the child.
●Make sure you have complied with all insta llation instructions provided by the child
restraint manufacturer and that the system is properly secured. If it is not secured
properly, it may cause death or serious inju ry to the child in the event of a sudden
stop, sudden swerve or accident.

681-2. Theft deterrent system
ES350_OM_OM33B64U_(U)
■System maintenance
The vehicle has a maintenance-free type alarm system.
■Items to check before locking the vehicle
To prevent unexpected triggering of the alarm and vehicle theft, make sure of the follow-
ing:
●Nobody is in the vehicle.
●The windows and moon roof are closed before the alarm is set.
●No valuables or other personal items are left in the vehicle.
■Triggering of the alarm
The alarm may be triggered in the following situations:
(Stopping the alarm deactivates the alarm system.)
■Alarm-operated door lock
In the following cases, the door may automatically lock:
●When a person remaining in the vehicle unlocks the door and the alarm is activated.
●While the alarm is activated, a person remaining in the vehicle unlocks the door.
●When recharging or replacing the battery.
●A person inside the vehicle opens a door, the
trunk or hood, or unlocks the vehicle using an
inside lock button.
●The battery is recharged or replaced when the
vehicle is locked. (P. 5 0 3 )
NOTICE
■To ensure the system operates correctly
Do not modify or remove the system. If modified or removed, the proper operation of
the system cannot be guaranteed.

89
ES350_OM_OM33B64U_(U)
3
Operation of
each component
3-1. Key information
Keys .................................................... 90
3-2. Opening, closing and locking the doors and trunk
Doors ................................................. 93
Trunk ................................................... 99
Smart access system with push-button start ............ 106
3-3. Adjusting the seats Front seats ........................................ 114
Driving position memory ........... 115
Head restraints .............................. 119
3-4. Adjusting the steering wheel and mirrors
Steering wheel ..............................122
Inside rear view mirror............... 124
Outside rear view mirrors ........126
3-5. Opening, closing the windows and moon roof
Power windows .............................129
Moon roof ...................................... 132